Discovery of Dual-Disease Targeting Phosphodiesterase Inhibitors from Uvaria alba DCM Sub-Extract with Potential Anti-Cancer and Anti-Neurodegenerative Therapeutic Properties: Insights from in vitro and Consensus Virtual Screening
Delfin Ynigo H. Pilapil | Mark Tristan J. Quimque | Kin Israel R. Notarte | Allan Patrick G. Macebeo
Abstract:
Many complex diseases such as cancer and neurodegenerative disorders are related to multiple pathological manifestations. Moreover, drugs for their treatments often have serious side effects. Thus, it is important to discover multi-indication therapeutics that can both target a wide array of interest diseases and limit side effects. However, classic one-drug-one-disease protein drug discovery paradigms and budding polypharmacology approach rarely solve the hurdles of multi-indication drug design.
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