Mutagenicity and Clastogenicity Potential of Five Philippine Medicinal Plants

D. M.  Zhang,; C.y.  Ang,; B.  Basilio,; L.c.v.  Mendoza,; M.c.  Villena,

Mutagenicity and Clastogenicity Potential of Five Philippine Medicinal Plants

C.y. Ang | B. Basilio | L.c.v. Mendoza | D. M. Zhang | M.c. Villena

Discipline: agriculture food and related studies

Abstract:

Expressions fromrhizomes of Acorus calamus Linn., decoctions from leaves of Cassia tora Linn., seeds of Glycine max CLinn. Merr., tubers of Kaempferia galangaLinn. and roots of Vetiveria zizanioides Stapf. were studied for mutagenicity andclasiogen- icitypotential using Rec assay, Ames test, host-mediatedassay andmicronucleus test. The plant test systems didnot possess direct DNA dammaging capacity. These were not mutagenic before and after metabolic activation. No chromosome breakingeffects were observed.

References:

Kirtikar, K. R., & Basu, B. D. (1918). Indian medicinal plants. Allahabad.
Greenish, H. G. (1920). A textbook of materia medica (3^rd ed.). J. & A. Churchill.
Honigberger, J. M. (1852). Thirty-five years in the East. H. Bailliere.
Hooper, D. (1937). Useful plants of Iran and Iraq (Botany Series, Vol. 9, No. 3). Field Museum of Natural History.
Parry, E. J. (1908). The chemistry of essential oils and artificial perfumes. Scott, Greenwood & Son.
Dastur, J. F. (1962). Medicinal plants of India and Pakistan. D. B. Taraporevala Sons & Co.
Chopra, R. N. (1933). Indigenous drugs of India. Art Press.
Quisumbing, E. (1978). Medicinal plants of the Philippines. Katha Publishing Company.
Burkill, I. H. (1930). Malayan village medicine. The Gardens’ Bulletin, Straits Settlements, 6(1-3), 165–321.
Nadkarni, K. M. (1927). Indian materia medica. Bombay.
Brown, W. H. (1951). Useful plants of the Philippines (Technical Bulletin 10, Vol. 1, pp. 98–104). Bureau of Printing.
Guerrero, L. M. (1921). Medicinal uses of Philippine plants (Bureau of Forestry Bulletin No. 22, pp. 22–170). Bureau of Printing.
Kada, T., Hirano, K., & Shirasu, Y. (1980). Screening of environmental mutagens by the Rec-assay system with Bacillus subtilis. In F. J. de Serres & A. Hollaender (Eds.), Chemical mutagens: Principles and methods for their detection (Vol. 6, pp. 149–171). Plenum Press.
Ames, B. N. (1971). The detection of chemical mutagens by enteric bacteria. In F. J. de Serres & A. Hollaender (Eds.), Chemical mutagens: Principles and methods for their detection (Vol. 1, pp. 267–281). Plenum Press.
Moriya, M., Kato, K., Ohta, T., Watanabe, K., & Shirasu, Y. (1978). Detection of mutagenicity of the host-mediated assay. Journal of the National Cancer Institute, 61(2), 457–460.
Schmid, W. (1976). The micronucleus test. In F. J. de Serres & A. Hollaender (Eds.), Chemical mutagens: Principles and methods for their detection (Vol. 4, pp. 31–52). Plenum Press.