Home⇛The Philippine Journal of Biochemistry and Molecular Biology (PJBMB)⇛vol. 3 no. 1 and 2 (1980)

Mutagenicity and Clastogenicity Potential of Decoctions and Infusion from Philippine Medical Plants

C.y. Lim-sylianco | J.a. Concha | J. San Agustin | I. Panizares | C. Pablo

 

Abstract:

The Philippine National Formulary lists Philippine plants whose decoctions and infusions are used for medicinal purposes. Mutagenicity potential of these decoctions and infusions were studied without metabolic activation and after metabolic activation. Without metabolic activation, decoction from leaves of Plantage major L. and decoctions from leaves and bark of Pittosporum pentandrum {Blanco) Merr. induced frameshift muta­genesis in Salmonella typhimurium. After metabolism in the experimental mice, these induced both base-pair and frameshift mutagenesis. Decoctions from bark of Pitchecolobium dulce {Roxb) Benth. induced base-pair muta­genesis without metabolic activation. Upon metabolic activation in the mice, this tendency was lost. Instead it induced frameshift mutations. Decoctions from stems of Arcangelisia fava (L.) Merr. induced both base­pair and frameshift mutations without metabolic activation. However, this mutagenic property was lost upon metabolism in the experimental mice.



References:

  1. Concha, J. A. (Ed.). (1978). The Philippine national formulary (1st ed.). National Science Development Board.
  2. Sylianco, C. Y. L., Luistro, A., & Panizares, I. (1977). Mutagenicity studies of aqueous extracts of comfrey (Symphytum officinale Linn.). National Research Council of the Philippines (NRCP) Research Bulletin, 32(2), 178–191.
  3. Ames, B. N. (1971). The detection of chemical mutagens with enteric bacteria. In A. Hollaender (Ed.), Chemical mutagens: Principles and methods for their detection (Vol. 1, pp. 267–282). Plenum Press.
  4. Gabridge, M. G., & Legator, M. S. (1969). A host-mediated microbial assay for the detection of mutagenic compounds. Proceedings of the Society for Experimental Biology and Medicine, 130(3), 831–834.
  5. Schmid, W. (1976). The micronucleus test for cytogenetic analysis. In A. Hollaender (Ed.), Chemical mutagens: Principles and methods for their detection (Vol. 4, pp. 31–53). Plenum Press.

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