Mutagenic and Clastogenic Effects of Chloroform

Clara  Lim-sylianco,; Jovenal  San Agustin,

Mutagenic and Clastogenic Effects of Chloroform

Jovenal San Agustin | Clara Lim-sylianco

Abstract:

Chloroform was shown to exhibit DNA damaging capacity. However, its ONA damaging capacity is not a consequence of its direct reactivity with DNA. Directly it did not effect base pair and frameshift mutations. But chloroform it metabolized to a frameshlft mutagen in the male mouse. Thus, chloroform is a pro-mutagen although it is not a direct mutagen. It is not only a pro-mutagen but also a clastogen (chromosome breaking). Its clastogenicity and mutagenicity, however, is reduced in the presence of vitamin E.

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