Yak (Poephagusgrunniens L.) is an important animal of the highlands distributed throughout the harsh environment of the Himalayan mountain range. However, the animal often exhibits poor productivity and calf viability. Vitamin E and selenium are important antioxidants and play an important role in udder immunity and calf viability. Therefore, a study was designed to determine the efficacy of parenterally administered vitamin E and selenium during the late gestation period on certain productive characteristics of yaks and their calves. Altogether 21 yak cows were randomly divided into three groups with seven animals per group. Treatment 1 received no drug and served as the Control. Treatments 2 and 3 received a commercial preparation containing DL-alpha tocopheryl acetate equivalent to tocopherol (Vitamin E) 50 mg/ml and sodium selenite 1.5 mg/ml administered intramuscularly twice at 7 days interval 30-40 days prior to expected calving at the rate of 5 ml and 10 ml for Treatments 2 and 3, respectively. The results showed that intramuscular administration of 10 ml of Vitamin E and selenium preparation to yak cows during late gestation can significantly (P<0.05) increase milk yield and lactation length and improve calf viability.