The eﬀects of Serpentina (Andrographis paniculata) and Papait (Mollugo oppositifolia L.) aqueous extracts on blood glucose and cholesterol levels of 24 alloxan-induced diabetic 6-8 weeks old ICR male mice were investigated. The animals were distributed equally in a completely randomized design into three treatment groups with T1- Metformin at 500mg/kg, T2- Serpentina and T3-Papait at 400mg/kg BW PO. The substances were administered orally bid for 14 days. Blood glucose and cholesterol were determined using wet reagent chemistry. Blood glucose levels of all the animals in the treatment groups were greater than 200mg/dl, however T3 showed a consistent blood glucose lowering eﬀect from day 0 to 14 causing 36.07% reduction compared to T2 which caused a ﬂuctuating eﬀect on blood glucose levels and a reduction of 22.53% while the animals in T1 showed the highest reduction at 45.29%. Also, animals in T3 at day 14 post administration (322.93 mg/dl) had comparable blood glucose levels (p>0.05) with T1 (284.50 mg/dl). No signifcant diﬀerences were observed in the cholesterol levels. Results showed that Papait has comparable blood glucose lowering activity with Metformin as compared to Serpentina.