The anesthetic duration and cardiopulmonary effects of tiletamine-zolazepam were compared in 16 goats using a 4 × 4 Latin square design. Tiletamine-zolazepam was administered at a dose of 5.5, 4.5, 3.5 and 2.5 mg/kg in T1, T2, T3 and T4 respectively. Additionally, 0.1 mg/kg xylazine was added as a bolus mixture to T2, T3 and T4. The anesthetic combinations were given IV to effect. The pulse rate, respiratory rate, temperature, peripheral capillary oxygen saturation (SpO2), electrocardiogram (ECG), and pain response were measured at 15 min intervals. The onset and duration of anesthesia and time to standing recovery were likewise recorded. Results show that T3 had the fastest onset of anesthesia and the duration of anesthesia was shortest for T1 and progressively increased from T4 to T2. Depression in PR, RR, temperature and SpO2 was more signifcantly pronounced in T4 while ECG abnormalities were more frequent in T1. Results show that the addition of xylazine to tiletamine-zolazepam increases the duration of anesthesia without any signifcant adverse effects on the cardio-respiratory function or the frequency of cardiac arrhythmias in anesthetized animals. Tiletamine-zolazepam alone does not provide adequate analgesia for surgery.