Screenhouse and field experiments examined the potential of actinomycete as microbial inoculants to enhance the growth and yield of upland rice. Te actinomycete used solubilizes phosphorus, produces indole-3-acetic acid (IAA) and 1-aminocyclopropane-1-carboxylate (ACC) deaminase. In the screen house, at full rate of fertilization (RRF), actinomycete inoculation significantly increased shoot phosphorus uptake by 117% and grain yield by 128% relative to the uninoculated treatment. Response to inoculation was observed in the feld in terms of significant increases in plant height, root depth, tiller number and grain yield. Grain yield at RRF, ½ RRF + inoculation and RRF + inoculation were not significantly diﬀerent. Full fertilizer treatment increased mean grain yield by 21% relative to ½ RRF + inoculation. On the other hand, at ½ RRF, inoculation significantly increased grain yield by 101% an indication that inoculation has the potential of reducing fertilizer input by half. Te enhanced growth and P uptake, and the significant increase in grain yield due to inoculation demonstrate the potential of actinomycete as plant growth-promoting inoculants for upland rice. However, further fled assessment is needed to provide more information on the eﬀect of biotic and abiotic stresses on the electiveness of the inoculants.