The study investigates the relationship between the personal problems and depression among college students. Three hundred ninety three (393) first year college students participated in the study. They ranged in age from 16 to 17 years old. The sample purposively considered students enrolled across programs: fine arts, business administration, engineering, and arts and sciences. Descriptive analysis revealed that parents are frequent source of problems for first year college students. Based on estimated correlation, personal problems and depression are significantly related. Regression analysis was utilized to determine which of the personal problems had the most effect on depression and results indicate that problem situations involving parents were found to be the crucial factor. Of the 393 participants in the study, one hundred twelve (112) or almost thirty percent (30%) of the first year college students who participated in the study are suffering from “borderline” to “extreme” levels of depression. Moreover, it was found that almost half (186 or 47%) of the respondents perceived that they cannot count on adults (e.g., teachers, guidance counselors, school administrators) at their school for emotional support. Results of the study highlight the importance of mental health, psychological wellness, and counseling among adolescents.