This study focused on developing comparable models in surfacing the impact of job rotation characteristics on the job satisfaction of Filipino nurses in public and private hospitals. A total of 393 staff nurses were surveyed using both adopted and adapted tools measuring the constructs of the study. Using SPSS v.17, exploratory factor analysis (EFA) revealed the underlying dimensions of autonomy, namely: work execution and task scheduling; and job satisfaction, such as organizational support and organizational culture. Notably, with the use of AMOS v.16, the emerged structural equation model (SEM) revealed interesting causal and non-causal relationships among the constructs. Both nurses in public and private hospitals found that both dimensions of autonomy as well as skill variety and workload are correlated. Also, nurses’
satisfaction with organizational support and organizational culture are promoted by their work execution and workload, respectively. Surprisingly, they did not perceive skill variety as a significant contributor to neither job satisfaction dimensions. Findings yielded by this study provided insights to human resource practitioners, as well as hospital administrators, as how best to maximize the use of job rotation in the workplace that can still possibly elicit satisfaction among nurses.