Forty sexually mature, 1-5 years old Philippine domestic cats with body weight of 1-3 kg, were subjected to tiletamine-zolazepam (TZ) and to tiletamine-zolazepampropofol (TZP) anesthetic combinations. TZ at 2.5 mg/kg (T2; n=10), 3.75 mg/kg (T3; n=10) and 5.0 mg/kg (T4; n=10) were combined with a constant dose of propofol (6 mg/kg) and compared with TZ at 5 mg/kg (T1; n=10) in terms of onset and duration of anesthesia, sternal and standing recovery times, vital signs, peripheral capillary oxygen saturation (SpO2), obliteration of reflexes and presence of atrioventricular (AV) blocks. T2, T3 and T4 had a more rapid onset of anesthesia than T1. Both T3 and T4 exhibited significantly longer duration of anesthesia and obliteration of pupillary reflexes, as well as longer sternal and standing recovery times than other groups. Cats subjected to T3 had significantly higher SpO2 while T4 had the lowest AV blocks compared to other groups. The results show that propofol, in combination with tiletamine-zolazepam at 3.75 mg/kg or 5.0 mg/kg, can provide a faster onset, and longer and better quality of anesthesia than tiletamine-zolazepam alone in Philippine domestic cats.