Hypertension (HPN) is the elevation of arterial blood pressure with a systolic pressure of 140 mmHg or greater and a diastolic pressure of 90mmHg or more. The study aimed to determine the compliance on medication regimen among unit heads or unit managers. Te study utilized the descriptive-correlational research design to determine the relationships between variables. The participants were the 46 Unit Heads/Unit Managers chosen by means of purposive sampling. Questionnaire was the main tool for data gathering. Te data were analyzed using percentage distribution, weighted mean, standard deviation, Pearson Moment Correlation Coefficient, and Multiple Regression Analysis. The findings revealed that majority of the respondents had a monthly income of 16,000 (364 USD) to 20,000 (455 USD), have 4 to 6 children, chairpersons of a department in a government agency, and has antihypertensive medications for less than a year up to five years. Likewise, majority of the participants were diagnosed with Stage 2 HPN and currently taking two types of antihypertensive medications. Majority strongly agreed on the information about hypertension. Lifestyles regarding diet as well as attitude are predictors for compliance to antihypertensive medication.