The study determined the analgesic activity of the formulated syrup of Cashew (Anacardium occidentale) crude leaf extract on albinorats. Preliminary tests were employed such as phytochemical screening that detected positive with alkaloids using Mayer’s and Dragendoff’s tests and Fourier Transformed Infrared Spectroscopy (FTIR) identified the functional groups as alcohol, amines, amine salts, heterocyclic amine, phosphorous containing organic molecule, aldehydes, ether and ester. The acute oral toxicity of leaf extract showed no signs of toxic reaction hence, classified under category 5 based on the OECD 423 guidelines. Approximate Effective Dose (AED) crude extract was 630.98 mg/kg that showed the lowest number of seconds the rats spent in biting and licking the paw. These were the bases of formulating the crude extract into syrup. Bioassay of the syrup was done using female rats by showing the biting and licking of the paw. Three groups such as positive control (Ibuprofen), test drug and negative control (Plain syrup) were compared. Analysis of Variance interpreted that it has significant different between Ibuprofen and test drug. Post hoc multiple comparison test showed that the ibuprofen has the highest activity than the cashew leaf syrup.