The study evaluated the anti-angiogenic and antioxidant properties of Sayote (Sechium edule) ethanolic leaf extract. Quantitative phytochemical analysis was done by estimating the total phenolic content by gallic acid in Sayote ethanolic leaf extract. To determine the anti-angiogenic property of the extract, Duck Chorioallantoic Membrane (CAM) Assay was employed. Results of the experiment showed that the ethanolic leaf extract has no median lethal concentration (LC50) since not more than 50% of the population of brine shrimp eggs died. It was found out that there is a significant difference between the antiangiogenic effects of the different concentrations of the leaf extract and that of the 95% ethanol as negative control in 11-day chick embryo chorioallantoic membrane. The formation of the branches of blood vessels is dependent on the treatment concentration: 5% concentration exhibited the least anti-angiogenic property while 15% showed the highest. In the antioxidant property, 2-2diphenyl-1-picrylhydrazyl hydrate (DPPH) assay was performed and result showed a significant difference between the antioxidant property leaf extract concentration and ascorbic acid (positive control). Results of the assay clearly indicated that the inhibition of free radical formation is directly proportional to the concentration of extract. The 0.5% of Sayote exhibited the highest antioxidant property.