Philippine E-Journals

EVALUATION OF MANGO (Mangifera indica) PEEL DERIVED PECTIN AS PHARMACEUTICAL BINDER

Kathleen G. Bersabal | Ferlien Mae G. Baula | Mary Angelie V. Agustin | Baby Bia B. Manongtong | Gridlin A. Matilac | Karl Eric P. Pandian

 

Abstract:

Pharmaceutical excipients that developed from waste products are economical because they are coming from natural sources. The present study aimed to extract pectin from Mango peels (Mangifera indica) and exploring its property as binding agent. Extracted mango pectin was evaluated with its capacity to bind by determining the presence of carbohydrates through Molish’s, functional groups present by FTIR spectroscopy, physic-chemical characterization by determining its ash content, pH value, solubility behavior, surface tension, loss on drying, bulk and true density, powder flow property and powder compressibility based on the standards set by USP/NF (1995). Acetaminophen tablets containing starch as a binding agent was used as standard for comparison with the Acetaminophen tablets with pectin as binding agent. On the other hand, mango pectin and starch were compared individually as tablet binder in Paracetamol tablet formulation. Formulated tablets were prepared following the standards of USP/NF. Results have shown no significant difference between the mango pectin and starch in post-compression analysis of the formulated tablets in terms of the disintegration and dissolution. It was also revealed that in hardness test there is a significant difference in the binding capacity of pectin being much harder than starch. Meanwhile, friability test was less than one percent. These test results conform to the specification and standards set by USP/NF. Study revealed that mango pectin is comparable to starch as binding agent. Mango peels were considered waste products and utilizing it can help the environment.