Alternative medicine from herbal plants is an option for treatment by people in the middle and marginalized sectors. With this, the study focuses on the determination of acute dermal toxicity and antibacterial activity of the combined leaf extracts of Makahiya (Mimosa pudica) and Bayabas (Psidium guajava) against Staphylococcus aureus and Pseudomonas aeruginosa. Specifically, Acute Dermal Toxicity was conducted at doses of 1000 mg/kg and 2000 mg/kg of the combined extracts for the sighting study and 2000 mg/kg for the main study. Results show no positive signs of skin toxicity. The antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was determined through disk diffusion assay. Findings reveal that the extracts have a weak antibacterial activity against P. aeruginosa and moderate antibacterial activity against S. aureus.