The ultimate aim of this investigation is to determine the significant contribution of research commercialization of Higher Education Institutions in Region XI on their economic sustainability and commitment to economic development of the region. Using mixed method via triangulation technique, the study infers that the mindset of the respondent universities is not yet for research commercialization. This inference is drawn from the following findings: there are enough inventions and innovations in universities but their research commercialization is still less extensive; the degree of the contribution of research commercialization to their own economic sustainability is low at 14.6 % but is statistically significant. The level of their commitment to economic development of the region is high but the degree of the contribution of research commercialization to such commitment is very low at only 7.3% and not statistically significant. This means that 85.4% of economic sustainability of universities and 92.7% of their commitment to economic development of the region are contributed by other factors aside from research commercialization. This implies that any increase in the level of research commercialization will have a corresponding effect on the level of its contribution to the universities own economic sustainability but not to their commitment to the economic development of the region.