There is a great challenge to enhance the research publication productivity among faculty of higher education institutions. The goal of this study was to find out the determinants of the research publication productivity of faculty in Higher Education Institutions in Region XI. Thereupon, the results can be used to enhance Higher Education Institution research program. The study made use of the descriptive correlation design which measured the relationship of demographic profile, research capability and institutional research support to research publication productivity of faculty. A self-made survey questionnaire consisting of four parts namely Faculty Demographic Profile, Research Capability, Institutional Support and Publication Productivity was utilized. Purposive Sampling Technique was employed in the study wherein a total of 200 faculty respondents from higher education institutions participated. Frequency and Percent, Mean and Standard Deviation were used together with Multiple Regression Analysis. The findings revealed that the level of research capability among higher education faculty is high with a mean value of 3.77 while the institutional research support has a mean value of 3.22 which is described as average. Meanwhile, the publication productivity among Higher Education Institution faculty in Region XI is only at 21%. Moreover, the institutional research support comprising training, research infrastructure and budget allocation significantly influence the publication productivity of faculty in higher education institutions in Region XI.