Common bacterial infections are eliminated by means of commercially available antibiotics. Nonetheless, the presence of resistant strains of bacteria leads to ineffective treatment. One of the plants who were believed to possess an antimicrobial property is the Mangifera indica. This study aims to prove the idea that there is a possibility that people can derive new drugs from this plant. Furthermore, this study intends to find out if there will be significant difference on the activity of ripe and unripe seed and fruit extracts against Staphylococcus aureus (ATCC 25923) and Pseudomonas aeruginosa (ATCC27853). The different plant extracts together with the positive and negative controls were impregnated into disks and placed into the agar plates to determine their zones of inhibition against the test bacteria. Statistical analysis showed a significant difference on the action of mango extracts against S. aureus and P. aeruginosa. Ripe fruit extract showed no activity against P. aeruginosa while ripe and unripe seed extracts were active with the ripe seed extract showing the highest inhibitory action.