Distinct individuals show different emotional responses and attitudes in a different environment. During transitions, students are required to adjust academically, socially and emotionally. The personality trait, is a dynamic and structured set of characteristics owned by an individual that uniquely influence his/her environment, cognitions, emotions and behavior in different circumstances. With this, the researchers determined if there is a significant association between the personality traits and the extent of adjustment in academic, social and emotional domains of the grade-11 senior high school students of the University of the Immaculate Conception. The researchers used a 50-item Big Five Factor Marker for personality traits and a 30-item researcher-made questionnaire for the Level of Adjustment with 256 respondents as sample size from 763 total population of senior high school students. After the test of significant correlation the researchers found that conscientiousness and agreeableness has a significant association on the academic, social, and emotional adjustment. This reveals that these personalities have a relationship towards the senior high school students’ academic, social and emotional adjustment, which implies that if a person scores high on conscientiousness and agreeableness, he/she will be able to adjust well on generally on the three domains of adjustment.