While quality feeds and proper feeding practices for larval rearing of tilapia fry has been established, another cheap source of protein from plant sources has not been fully explored. In this study, the potential of Trichanthera gigantea leaf meal on the diet of O. niloticus fry was determined in four treatments (Treatment 1, 75% TG + 25% Fm; Treatment 2, 50% TG + 50% Fm; Treatment 3, 25% TG + 75% Cd; and Treatment 4, 100% Cd without TG, as control), with three replicates each and arranged in a complete randomized design. Each treatment was stocked with fifty (50) tilapia fry with an average body weight of 0.42 g and an average body length of 27 mm and reared for two months. Growth and survival of tilapia were sampled every two weeks, while monitoring of water temperature was done daily. One Way Analysis of Variance was used to determine significant difference among treatments at 0.05 alpha. Results showed that fish fed 75% TG with 25% Fm had significantly (p>0.05) higher ABW (4.29+ 0.242g), ABL (62.45+0.312 mm), and SR (90.40+0.561%) at the end of the culture compared from the rest of the treatments. Tricanthera gigantea can be a potential leaf meal supplementation on the diet of O. niloticus fry.