Suicide cases have been prevalent in college students nowadays. The high standards placed upon them by society or themselves contribute to an individual’s suicidal desire. Perfectionists tend to have deficits in emotion regulation and emotionally dysregulated individuals have higher risks for suicidal desire. This study provides an analysis and evaluation of how emotion dysregulation mediates the relationship of perfectionism and suicidal desire. A survey was conducted among 200 college students. Mediation analysis using Model 4 of the Conditional Process Analysis by Hayes and Sobel test was used to analyze the data. Results of the data show that all relationships are significant. In particular, perfectionism was found to be a predictor of suicidal desire. Moreover, emotion dysregulation partially mediates between perfectionism and suicidal desire. The study finds that college students have high standards for themselves and failure to achieve these may lead to suicidal desire. The study also finds that college students do not regulate their emotions well when not meeting their standards which may lead to a person’s suicidal desire.