In response to the challenge of global education, St. Paul University Philippines launched its internationalization program prompted by the tagline: Making a Difference Globally. This study aimed to come up with a framework to develop intercultural competence for global education. The results show a framework that illustrates the interplay of the cognitive, affective, and behavioral dimensions of intercultural competence. Accordingly, the cognitive element comprises of the knowledge, awareness, understanding, study, learning, pre-judgment and bias. The affective element includes the attitudes, values, sentiments, curiosity, openness, care, concern and difficulty. The behavioral aspect encompasses the skills, observable conduct and gestures, countenance and interactions. There are also internal and external outcomes which consist of reflections, insights, and outputs. The development of intercultural competence is facilitated by international experience, global learning and international partnerships and linkages. Internationalization programs and strategies to develop intercultural competence for global education were likewise suggested