Three promising mulberry varieties viz; Alfonso, Alf-004 and Alf-025 and five vermicomposted seri-waste (VC) rates as follows: R1- (0 Fertilizer); R2- (10 tons/ha VC); R3- (20 tons/ ha VC); R4- (10 tons VC + ½ RR) and R5- (150kg/ ha Urea) and its interaction effects of mulberry varieties x fertilizer treatments were evaluated to investigate on the effect of VC as organic fertilizer for mulberry sapling production. Factorial -Randomized Completely Block Design with three replications. Data were analyzed using two –way ANOVA to determine significant interactions, simple and main effects, and further tested for differences among treatments using DMRT. For first cropping year, variety has influenced on sprouting, number and weight of roots, number of leaves, length of roots and shoots whereas as fertilizer rates has influenced weight of leaves and roots, root to shoot ratio by weight and length and weight of shoot. For second cropping year, variety influenced length of roots, number and weight of leaves, length of shoot and root to shoot ratio by weight. Weight and length of roots, weight of leaves, length and weight of shoots were influenced by the different fertilizer rates. No statistical variations were also observed on mulberry varieties x fertilizer rates for both the cropping years.