5S system is designed to create a "work environment that is self-explaining, ordering and improving.” The main objective of the study was to redesign warehouse items layout at Company XYZ using 5S system strategy. This study used applied research, which worked by moving from a theory review to a practical problem. The researchers were able to evaluate the awareness, importance, and areas where 5S could be applied in the company. The total warehouse area was 1428.612 sq.m. with a space utilization of 52.57%. From the proposed warehouse items layout, the researchers had saved a total space of 193.01 sq.m which was 13.51% of the total warehouse items space that was converted into receiving area and shipping area.