The main objective of this study is to determine the possible upper extremities affected by musculoskeletal disorder among engineering students in selected CALABARZON schools. Results show that majority of the respondents are male, 20 years old, taking Industrial and Civil Engineering programs. In terms of computer-related factors, most of the respondents have used both laptop and desktop since elementary, consume it for four or more hours, type moderately fast, consider doing a hunt and peck typing skill on both hands, and sit on chair. For mobile phone-related factors, majority of the respondents have used smart phones since elementary, consume it for four or more hours, and type fast using the thumb finger of both hands. There is a significant relationship between computer and mobile phone factors and the physical discomforts around the neck, shoulder, upper arm and wrist, hand and finger. As a result, the top three upper body parts where musculoskeletal disorders mostly occur are neck, shoulder, and wrist, hand, and fingers.