Utilization of hybrid rice offers 15 to 20 % yield advantage over inbred, thus offers a higher income to farmers. Anther culture technology advances the development of hybrid rice by increasing breeding efficiency and reducing cost. This study aims to develop rice hybrids crossed between cytoplasmic male-sterile lines as female parent and male pollen parent lines generated through anther culture. Hybrids were then evaluated in different nurseries viz., testcross nursery (TCN), observational nursery (ON), and preliminary yield trial (PYT). In TCN, three rice hybrids (PR48755H, PR48758H, and PR48765H) attained yield ranged of 5.8 tha-1 to 7.0 tha1 against released inbred check (PSB Rc18, PSB Rc82, NSIC Rc222 and NSIC Rc240) with only4.3 tha-1 to 5.5 tha-1 yield. Forwarded to ON, these hybrids yielded 6.1 tha1 to 10.3 tha1 as compared to the check varieties viz., Mestiso 19, Mestiso 20 and PSB Rc18 with 5.0 tha-1 to 6.1 tha1 . In PYT, they yielded 7.1 tha1 to 8.6 tha1 compared to the 3.3 tha1 to 5.6 tha-1 grain yield of the check varieties. These hybrids were identified moderately resistant to green leafhopper, while PR48755H and PR48758H were identified resistant to leaf blast and brown planthopper. The study proved the efficiency of anther culture in developing superior rice hybrids with increased yield thereby helping farmers’ increase rice productivity.