Acetaminophen also known as Paracetamol is an over-the-counter drug that is widely used as analgesic and antipyretic. It is generally considered safe when taken in the recommended dose (650 mg - 1000 mg every four (4) to six (6) hours). However, when taken in relatively large amount or overdosed, it tends to lead to hepatotoxicity and acute liver failure. Ipomea aquatica shows hepatoprotective property due to its certain effective component that exerts antioxidant capacities in vivo. In this study, the researchers investigated the hepatoprotective effect of I. aquatica methanolic extract against acetaminophen- induced liver damage in Sprague dawley rats. Results confirm that many of the slides showed no apparent lesion. The only lesion observed was the presence of generalized cloudy swelling. This kind of lesion was prevented in most of the liver given with water spinach extract. The dose of 1 g/kg had the same effect as the 2 g/kg extract. Based on the data obtained, the study concludes that the kangkong extract had apparently prevented the formation of lesion known as cloudy swelling or cytoplasmic granulation.