This research evaluated the effectiveness of the Mindanao State University System (MSUS) and its Colleges of Agriculture, as an educational institution that provides agricultural education. The study was conducted in 4 major campuses of the MSU System having well-established Colleges of Agriculture namely: MSU Marawi, MSU Maguindanao, MSU General Santos and MSU Sulu. The research design used is descriptive employing the survey technique. Supplemented by individual and group interviews. The non-random purposive sampling technique was utilized in the selection of college officials, faculty members and support staff as respondents. The data were analyzed and interpreted using the following statistical techniques: weighted mean, analysis of variance one way classification (F Test), and Multiple Linear Regression Analysis. The overall level of effectiveness in the performance of the four-fold functions is only “Good” while the overall assessment of its existing organizational components is Uncertain. There are significant differences in the ratings of the three groups in some of the functions while there are no significant differences in the ratings of all organizational components; and 3) Out of 11 indicators, two of them, Statement of the VMGO and, the Dissemination and Acceptability, turned out to have significant relationship with the performance effectiveness.