Mosquitoes are the most dangerous insect pests that affect humans and animals worldwide as they transmit epidemic and fatal diseases. The study was conducted to find out the effect of indigenous plants as alternative larvicide toward anopheles’ species. This was tried in different concentrations of Nauclea subdita Steud, Homonoia riparia Lour, Physalis minima Linn, and Tabernaemontana pandacaqui Poir with both positive and negative controls. This study utilized the Completely Randomized Design (CRD) with five (5) treatments replicated 3 times. The following served as the treatment of the study. T0- negative control (Pure water), T0+ positive control (Baygon), T1- 30% concentration, T2- 60% concentration, T3- 90% concentrations of the 4-plant extract. The result shows that Physalis minima at 90% concentration is the most effective indigenous plant for average time mortality and average mortality number whether laboratory or field application.