Considered as a major public health concern, dengue is measured as a leading vector-borne viral disease transmitted by mosquitoes to humans. It is also an emerging disease. The drastic changes noted in the recent epidemiology of the disease are increasing morbidity-mortality and geographical factors. It currently threatens the world's population and remains a puzzling disease in many ways, such as the relationships between virus-vector and host-virus, and variability in clinical expression. The study sought to explain the trends in the country's dengue research specifically in Region IV-A. The researchers seek for different databases and identify published studies in the Philippines. In this research paper, the relationship between various climatic factors and the clinical cases of dengue in the Region IV-A CALABARZON from the year 2012-2018 was determined, where the disease is of major concern, to better understand the forms of dengue research and key findings and gaps. This study is a quantitative research design in a descriptive correlational method, and it covered the Region IV-A CALABARZON which consists of the provinces of Cavite, Laguna, Batangas, Rizal, and Quezon. The data used in this study were archived from the Department of Health (DOH) and Philippine Atmospheric, Geophysical, and Astronomical Services Administration-Department of Science and Technology (PAGASA-DOST). The findings suggest that there is an association between climatic factors and dengue cases in the provinces in the region on the gathered data from 2012 to 2018.