Philippine E-Journals

Molecular Engineering of Iron Phthalocyanine Complex for Potential Photomagnetodynamic Therapy Application

Lauren Beatrice G. See | Staceyann U. Seng | Joey A. Valinton | Derrick C. Yu

 

Abstract:

A modified iron-centered phthalocyanine complex was synthesized with axial aminopyridine ligands. The aminopyridine was coordinated with the central metal of the phthalocyanine through dissociative ligand substitution to create terminal amines, which would bond with the growth factors in proteins. This complex may exhibit higher absorption which may help penetrate the tumor tissues better while its paramagnetic properties allow the monitoring of its activity inside the body in the presence of a magnetic field. Characterization using infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, melting point, and solubility tests were performed to substantiate the formation of the [FeIII(Pc)(ampy)2]SCN.