Toxicity and Teratogenicity Assessment Using Zebrafish (Danio rerio) Embryo of Synthesized Zinc Oxide Nanomaterials Grown via Horizontal Vapor Phase Growth Technique
Jasper James D. Chang | Gil Nonato C. Santos | Oliver B. Villaflores | Custer C. Deocaris
Abstract:
The study investigated the effect Zinc Oxide nanoparticle structures on the toxicity and teratogenicity towards zebrafish. Varying structures of Nano-Zinc Oxide crystals were synthesized at sizes similar to commercially available 50 nm to 100 nm particles and exposed to zebrafish embryo for a span of 5 days conducting toxicity and teratogenicity assay. While previous studies debated the result of commercially available Zinc Oxide nanoparticles, the synthesized Nano-Zinc Oxide demonstrated definite toxicity. An interesting finding showed that at higher concentration the zebra fish were eradicated at an early stage of the experiment but lower concentration created higher mortality rate in the end.
References:
- Pietroiusti, A., Stockmann-Juvala, H., Lucaroni, F., &Savolainen, K. (2018, September 1). Nanomaterial exposure, toxicity, and impact on human health. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Vol. 10. https://doi.org/10.1002/wnan.1513
- Brannen, K. C., Panzica-Kelly, J. M., Danberry, T. L., &Augustine-Rauch, K. A. (2010). Development of a zebrafish embryo teratogenicity assay and quantitative prediction model. Birth Defects Research Part B - Developmental and Reproductive Toxicology, 89(1), 66–77. https://doi.org/10.1002/bdrb.20223
- Piccinno, F., Gottschalk, F., Seeger, S., &Nowack, B. (2012). Industrial production quantities and uses of ten engineered nanomaterials in Europe and the world. Journal of Nanoparticle Research, Vol. 14. https://doi.org/10.1007/s11051-012-1109-9
- Ladines, A. (2008). Synthesis and characterization of zinc oxide nanomaterials through horizontal vapor phase crystal growth. De La Salle University.
- Mueller, N. C., &Nowack, B. (2008). Exposure modeling of engineered nanoparticles in the environment. Environmental Science and Technology, 42(12), 4447–4453. https://doi.org/10.1021/es7029637
- Kachynski, A.V., Kuzmin, A. N., Nyk, M., Roy, I., &Prasad, P. N. (2008). Zinc oxide nanocrystals for nonresonant nonlinear optical microscopy in biology and medicine. Journal of Physical Chemistry C, 112(29), 10721–10724. https://doi.org/10.1021/jp801684j
- Chen, W. Y., Cheng, Y. H., Hsieh, N. H., Wu, B. C., Chou, W. C., Ho, C. C., …Lin, P. (2015). Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice. International Journal of Nanomedicine, 10, 6277–6292. https://doi.org/10.2147/IJN.S86785
- Nair, S., Sasidharan, A., Divya Rani, V.V., Menon, D., Nair, S., Manzoor, K., &Raina, S. (2009). Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells. Journal of Materials Science: Materials in Medicine,
- Halili, J. F. A., &Quilang, J. P. (2011). The zebrafish embryo toxicity and teratogenicity assay. Retrieved November 19, 2019, from https://www.researchgate.net/publication/313795945_The_zebrafish_embryo_toxicity_and_teratogenicity_assay
Full Text:
Note: Kindly Login or Register to gain access to this article.
Philippine E-Journals
