Effectiveness of Brassica juncea (mustard green) leaf decoction as an adjunct in the treatment of type 2 diabetes mellitus among Filipinos: a randomized clinical trial

Remigio Jay-ar  Z. Butacan,; Samantha Pauline  G. Chio,; Ma. Elaine  D. Chua,; Monica  B. Coralde,; Raphael Carlos  P. Covar,; Mariah Sandrine  M. Dating,; Janica Crissel  Y. Francisco,; Kryzta Kate  V. Gabay,; Bianca Marguerite  D. Gatbonton,; Jose Jonathan  F. Giron,; Herald Jervy  D. Go,; Clarissa Isabel  B. Hernandez,; Tsung-Jen  Hou,; Monaflor Abigail  G. Ignacio,; Anna Victoria  F. Ilagan,

Effectiveness of Brassica juncea (mustard green) leaf decoction as an adjunct in the treatment of type 2 diabetes mellitus among Filipinos: a randomized clinical trial

Abstract:

Introduction : This study aimed to determine the effectiveness of mustard green leaf decoction as an adjunct to drug treatment in controlling blood glucose among Filipinos with type 2 diabetes mellitus. Methods : Participants were randomly assigned to receive mustard green decoction or a placebo solution for eight weeks on top of their oral anti-hyperglycemic medication. Fasting blood sugar and complete blood counts were determined at baseline, Week 4 and Week 8, and compared within and across the two groups. Results : There was a decreasing trend in the blood sugar level in the mustard green group while the opposite was noted in the placebo group. The mean FBS levels of the mustard green group were significantly lower than that of the placebo group at the Week 8 determination (6.10 vs 8.69 mmol/ L, p = 0.004). The decrease in blood sugar level on the eighth week in the mustard green group was significant compared with the baseline level (p = 0.008). Conclusion : This study has demonstrated that the intake of Brassica juncea decoction can significantly decrease blood sugar levels among type 2 diabetics compared to metformin alone.

References:

Magtubo CA. Philippines' diabetes profile. MIMS Today [Internet]. 2016 Sep 26 [cited 2017 Nov 26]. Available from: https://today.mims.com/philippines-diabetes-profile
Tan G. Diabetes care in the Philippines [Internet]. 2015Nov-Dec; 81:(6), 863-9. Available from: http://www.annalsofglobalhealth.org/article/S2214-9996(15)01264-3/abstract
UNITE for Diabetes Philippines. Compendium of Philippine Medicine [Internet]. 2014 [cited 2017 Nov 26]. Available from: http://endo-society.org.ph/v5/wp-content/uploads/2013/06/Diabetes-United-forDiabetes-Phil.pdf
David MK. Patient education: diabetes mellitus type 2: treatment (beyond the basics) [Internet]. Diabetes mellitus type 2: Treatment. UptoDate; 2017 [cited 2017 Nov 26]. Available from: https://www.uptodate.com/contents/diabetes-mellitus-type-2-treatment-beyond-the-basics
Higuchi M. Costs, availability and affordability of diabetes care in the Philippines [Internet]. Foundation of Advanced Studies on International Development; 2009 [cited 2017 Nov 26]. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.176.6958&rep=rep1&type=pdf
ADA Diabetes Management Guidelines A1C Diagnosis [Internet]. National Diabetes Education Initiative. 2016 [cited 2017 Jan 12]. Available from: http://www.ndei.org/ADA-2013-Guidelines-CriteriaDiabetes-Diagnosis.aspx.htm
Vinagre AS, Della Santa Rubio A, Rönnau O, Pereira SF, et al. Anti-diabetic effects of Campomanesia xanthocarpa (berg) leaf decoction. Braz J Pharmaceut Sci 2010 Apr-Jun; 46(2): 2.
Rahmatullah M, Shefa TF, Hasan L, Hossain T, Ahmed S, Mamun AA, Islam R, Rahman S, Chowdhury MH. A Study on antinociceptive and anti-hyperglycemic activity of methanol extract of Brassica juncea (L.) Czern. Leaves in mice. Adv Nat Appl Sci 2010; 4(3): 221-5.
Diagnosing diabetes and learning about prediabetes [Inter net]. Arlington VA: American Diabetes

Association; c1995-2016. Available from: http://www.diabetes.org/diabetes-basics/diagnosis.

Kitalong C, Nogueira RC, Benichou J, et al. "DAK", a traditional decoction in Palau, as adjuvant for patients with insufficient control of diabetes mellitus type II. J Ethnopharmacol [Internet]. 2017 Jun [cited 2017 Oct

12]; 205: 116-22. Available fr om: https://www.antenna.ch/wp-content/uploads/2017/04/kitalong-et-al017.pdf

Mishra SB, Rao CV, Ojha SK, Vijayakumar M, Verma A, Alok S. An analytical review of plants for anti-diabetic activity with their phytoconstituent and mechanism of action. Int J Pharmaceut Sci Res 2009; 715(3): 29-46.
Khan BA, Abraham A, Leelamma S. Hypoglycemic action of Murraya koenigii (curry leaf) and Brassica juncea (mustard green): mechanism of action. Indian J Biochem Biophys 1995; 32(2): 106-8.
Ufelle SA, Ukaefiofo EO, Naboh EE, et al. The effects of crude methanol seed extract of Brassica juncea on haematological parameters in Wistar rats. Br J Pharmacol Toxicol 2011; 2(3): 123-6.
Singh U, Singh S, Kochhar A. Therapeutic potential of antidiabetic nutraceuticals. Phytopharmacology 2012; 2(1): 144-69