The purpose of this research was to determine the relationship between stress and performance of administrators of University of Mindanao. Employing survey method and descriptive-correlation analysis, two types of standardized questionnaires in gathering data with mean, t-test and Pearson Correlation as statistical tools, results established a very low correlation between stress and performance. However, it was not significant implying that stress was found to be non-determinant of job performance. Hence, periodic evaluation of the effectiveness of the instrument used for performance is highly recommended. Administrators must also be given training to improve their performance in all aspect of their job and that further studies are warranted to address other factors not included in the present study.