Home⇛Psychology and Education: A Multidisciplinary Journal⇛vol. 5 no. 8 (2022)

A Systematic Review and Meta-Analysis on the in Vitro Antiuroliathic Studies Utilizing Medicinal and Herbal Plants

Danica Amor Landero

Discipline: Education

 

Abstract:

Urolithiasis is one of the conditions that has found its medicine in nature. This research was conducted using a systematic review and meta-analysis of published journals from a number of reputable research sources. The goal of this meta-analysis is to find out whether medicinal and herbal plants have antiurolithiatic properties in in-vitro research. The heterogeneity between the studies was minimized by summarizing the various types of plant extracts used and evaluating the capacity of various solvents to prevent calcium oxalate formation, and the data were analyzed according to the percentage dissolution. The results revealed that the aqueous extracts of Kalanchoe pinnata, Chloris barbata , Gossypium Herbaceum Linn, Vigna radiata, and Euphorbia thymifolia Linn; methanolic extracts of Mentha piperita, and Vigna Mungo Linn; ethanolic extracts of Chloris barbata, Gossypium Herbaceum Linn, Euphorbia thymifolia Linn, Piper nigrum, and Syzygium cumini; hydroalcoholic extract of Euphorbia thymifolia Linn and butanolic extract of Digitaria sanguanalis exhibited antiurolithiatic effects since they significantly reduced calcium oxalate accumulation based on high percentage dissolution of the experimental kidney stone by the plant extracts as compared to the standard drugs used. The findings of this study can be used as a guideline for future researchers studying medicinal and herbal plants native to the Philippines.



References:

  1. Albers, J. (2012). Herbal and Synthetic Drugs: A Comparison. Green Living Articles.
  2. Alelign, T., & Petros, B. (2018). Kidney stone disease: an update on current concepts. Adv Urol, 2018:3068365.
  3. Alley, G. (2018, November 21). Blog. Retrieved from Alooma: https://www.alooma.com/blog/what-is-data-extraction
  4. Ammor, K., Bousta, D., Jennan, S., Bennani, B., Chaqroune, A., & Mahjoubi , F. (2018). Phytochemical Screening, Polyphenols Content, Antioxidant Power, and Antibacterial Activity of Herniaria hirsuta from Morocco. ScientificWorldJournal.
  5. Aromataris , E., & Munn , Z. (2020). JBI Manual for Evidence Synthesis. JBI.
  6. Aryal , S., Kuwar , P., & Thapa, C. (2007). Antiurolithiatic activity of selected plants extracts against calcium oxalate crystals. JOURNAL Of MEDICINAL PLANTS RESEARCH.
  7. Aryal, S., Kuwar, P., & Thapa, C. (2019). ANTIUROLITHIAC ACTIVITY OF SELECTED PLANTS EXTRACTS AGAINST CALCIUM OXALATE CRYSTALS. Journal of Medicinal Plants Research, 15, 172-177.
  8. Azarfar, A. (2020). Effect of Herbal Formulation “Cystone®” on Urolithiasis. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
  9. Bailey, J. (2014, September 22). Why Copyright Matters in R e s e a r c h . R e t r i e v e d fro m P l a g i a r i s m B lo g : https://www.ithenticate.com/plagiarism-detection-blog/why-copyrig ht-matters-in-research#.YSeW2o4zbIV
  10. Bateman, S. (2005). PHARMACEUTICAL ANALYSIS | Dissolution Testing. Encyclopedia of Analytical Science (Second Edition), Pages 101-106.
  11. Bawari, S., Negi Sah, A., & Tewari, D. (2018). Antiurolithiatic Activity of Daucus carota: An In vitro Study. Pharmacognosy Journal, 10,5,880-884.
  12. Botany, G. (2021). Go Botany. Retrieved from Native Plant Trust: https://gobotany.nativeplanttrust.org/species/herniaria/hirsuta/
  13. Boy, H. A., Rutilla, A. H., Santos, K. A., Ty, A. T., Yu, A. I., Mahboob, T., et al. (June 2018). Recommended Medicinal Plants as Source of Natural Products: A Review. Digital Chinese Medicine, 131-142
  14. Celik , H., Tasdemir , C., & Altintas , R. (2014). An overview of percutaneous nephrolithotomy. EMJ Uro, 3:46-52.
  15. Chen, Y., Gao, Z., & Duan, Z. (2017). Dissolution Testing of Solid Products. Developing Solid Oral Dosage Forms (Second Edition), 355-380.
  16. Cumpston, M., Mckenzie, J. E., & Thomas, J. (2021). The use of 'PICO for synthesis' and methods for synthesis without metaanalysis: Protocol for a survey of current practice in systematic reviews of health interventions. Research Gate, 9(678):678.
  17. Deering, S. (2019). Nature’s 9 Most Powerful Medicinal Plants and the Science Behind Them. Healthline
  18. Devkar, R. A., Chaudhary, S., Adepu, S., Xavier, S. K., Chandrashekar, K. S., & Setty, M. M. (2016). Evaluation of antiurolithiatic and antioxidant potential of Lepidagathis prostrata: A Pashanbhed plant. Pharmaceutical Biology, 54(07), 1237-1245.
  19. Erickson, S., Vrtiska, T., & Liesk, J. (2011). Effect of Cystone® on Urinary Composition and Stone Formation Over a One Year Period. PubMed Central, 863-867.
  20. Erickson, Vrtiska, & Lieske. (2011). Effect of Cystone(R) on urinary composition and stone formation over a one year period. Phytomedicine, 863-7
  21. Esquenazi, D., Wigg, M. D., Miranda, M., Rodrigues, H. M., Tostes, J., Rozental, S., et al. (2015). Antimicrobial and Antiviral Activities of Polyphenolics from Cocos nucifera Linn. (Palmae) Husk Fibers Extract. Brazilian Journal of Medical and Biological Research, 647- 652.
  22. Evan, A., Lingeman , J., Coe, F., & Worcester, E. (2006). Randall's plaque: pathogenesis and role in calcium oxalate nephrolithiasis. National Library of Medicine, 69(8):1313-8. doi: 10.1038/sj.ki.5000238
  23. Ferreira, R. T., Coutinho, M. S., Malvar, D., Costa, E., Florentino, I., Costa, S. S., et al. (2014). Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid from Kalanchoe pinnata. Evidence-Based Complementary and Alternative Medicine, 2014.
  24. Firenzuoli, F., & Gori, L. (2007). Herbal Medicine Today: Clinical and Research Issues. Evid Based Complement Alternat Med.
  25. Galor, S. W., & Benzie., I. F. (2011). Herbal Medicine. Herbal Medicine: Biomolecular and Clinical Aspects
  26. Garg, A. X., Hackam, D., & Tonelli, M. (2008). Systematic Review and Meta-analysis: When One Study Is Just not Enough. Clinical Journal of the American Society of Nephrology, 253-260.
  27. Gautam, G. (2021). A systematic review on nephron protective AYUSH drugs as constituents of NEERI-KFT (A traditional Indian polyherbal formulation) for the management of chronic kidney disease. Saudi Journal of Biological Sciences, 6441-6453.
  28. Gayer, G., Hertz , M., Stav , K., & Zissin , R. (2006). Minimally invasive management of urolithiasis. Semin Ultrasound CT MRI, 27:139-51.
  29. Goswami, M., Bhagta, S., & Sharma, D. (2020). Melia dubia and its Importance: A Review. International Journal of Economic Plants 2020, 7(1): 029-033
  30. Goyal, P. K., Verma, S. K., & Sharma, A. K. (2017). Antiurolithiatic Potential of Neeri against Calcium-Oxalate Stones by Crystallization Inhibition, Free Radicals Scavenging, and NRK-52E Cell Protection from Oxalate Injury. Pharmacognosy Magazine, 549-554.
  31. Gurav, S. S., & Gurav, N. S. (2014). A COMPREHENSIVE R E V I E W : B E R G E N I A L I G U L A T A WALL – A C O N T R O V E R S I A L CL IN IC A L C A N D I D A T E . INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 1630- 1642.
  32. Hannes , K., & Lockwood , C. (2011). Pragmatism as the philosophical foundation for the Joanna Briggs meta-aggregative approach to qualitative evidence synthesis. J Adv Nurs, 1632–1642.
  33. Harshitha, N., Srivinya, A., & Ramanjaneyulu, H. (2018). EVALUATION OF IN VITRO ANTIUROLITHIATIC ACTIVITY OF CHLORIS BARBATA. International Journal of Pharmaceutical Research, 10(3), 65-67.
  34. Hegnauer, R. (2019). Calciumoxalat. Chemotaxonomie der Pflanzen
  35. Heilberg , I., & Schor, N. (2006). Renal stone disease: causes, evaluation and medical treatment. Arq Bras EndocrinolMetabol, 50:823-31.
  36. Hibbler, E. (2021, July 19). Copyright Basics. Retrieved from University of Michigan Library Research Guide: https://guides.lib.umich.edu/copyrightbasics
  37. Higgins , J., & Thompson , S. (2002). Quantifying Heterogeneity in a Meta Analysis. Statistics in Medicine, 21:1539-1558.
  38. Higgins , J., Thompson, S., & Spiegelhalter , D. (2009). A reevaluation of random-effects meta- analysis. Journal of the Royal Statistical Society: Series A (Statistics in Society) , 172(1):137–159.
  39. Hossain, M., Islam, M., & Numan, S. (2015). Multipurpose Uses of Bamboo Plants: A Review. International Research Journal of Biological Science, Vol 4(12), 57-60.
  40. Impellizzeri, F. M., & Bizzini, M. (2012). SYSTEMATIC REVIEW AND METAâ–ˇANALYSIS: A PRIMER. International Journal of sports Physical Therapy, 493-503.
  41. Jordan , Z., Lockwood , C., Munn , Z., & Aromataris , E. (2019). The updated Joanna Briggs Institute Model of Evidence-Based Healthcare. Int J Evid Based Healthc, 58-71
  42. Jorgensen , A., Hilden , J., & Gotzsche , P. (2006). Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: Systematic review. (BMJ333 :782 ).
  43. K, S. (2008). Medical aspect and minimal invasive treatment of urinary stones in children. Arch ItalUrolAndrol, 80:43-9.
  44. Kabilinadmin. (2018, June 27). Kabilin Bamboo. Retrieved from K a b i l i n N a t u r e F a r m s an d B a m b o o C e n t e r : https://kabilinbamboo.com/schizostachyum-lumampao/
  45. Kang, H. (2015). Statistical Considerations in Meta-Analysis. Hanyang Medical Reviews, 35(1): 23-32.
  46. Kannaian, U. N., Edwin, J. B., Rajagopal, V., Shankar, S. N., & Srinivasan, B. (2020). Phytochemical composition and antioxidant activity of coconut cotyledon. Heliyon.
  47. Karadi, R., Palkar, M., Gaviraj, E., Gadge, N., Mannur, V., & Alagawadi, K. (2009). Antiurolithiatic Property of Moringa oleifera Root Bark. Pharmaceutical Biology, 861-865
  48. Kaushik, S., Choudhary, M., & Rajpal , S. (2021). Antiurolithiatic efficacy of combination preparations of Dolichos biflorus and Crataeva nurvala: folk medicines used in Indian traditional medicine. Future Journal of Pharmaceutical Sciences volume, 7.
  49. Kazemi, S., Asgary, S., Moshtaghian, J., Rafieian, M., Adelnia, A., & Shamsi, F. (2010). Liver- protective effects of hydroalcoholic extract of allium hirtifolium boiss. In rats with alloxan-induced diabetes mellitus. National Library of Medicine
  50. Kazemipoor, M., Radzi, W. M., C, W. J., Cordel, G. A., & Yaze, I. (2012). Safety, efficacy and metabolism of traditional medicinal plants in the management of obesity: a review. International Journal of Chemical Engineering and Applications, 288-292.
  51. Khan, D. M. (2016). Introduction and Importance of Medicinal Plants and Herbs. National Health Portal.
  52. Khan, S. R. (1995). EXPERIMENTAL CALCIUM OXALATE NEPHROLITHIASIS AND. Scanning Microscopy, 89-101.
  53. Korets , R., Graversen , J., Gupta , M., Talati , J., Tiselius , H., Ye, z., et al. (2012). Dissolution of stones by oral and irrigative therapy. 533-7
  54. Lau, E. (2001). Preformulation Studies. Handbook of Modern Pharmaceutical Analysis, 173- 233.
  55. Li, W., & He, S. (2019). Research on the Utilization and Development of Bamboo. IOP Conf. Series: Earth and Environmental Science.
  56. Lima, E., Sousa, C., Meneses, L., Ximenes, N., Santos Junior, M., Vasconcelos, G., et al. (2015, August 18). Cocos nucifera (L.) (Arecaceae): A Phytochemical and Pharmcological Review. Brazilian Jornal of Medical and Biological Research2, 953-964
  57. Mamillapalli, V., Khantamneni, P. L., Mohammad, Z., Mathangi, A., Nandigam, N., Namburi, S., et al. (2016). PHYTOCHEMICAL & IN VITRO ANTIUROLITHIATIC STUDIES ON THE LEAF EXTRACTS . Internation Journal of Phamaceutical Sciences and Research, Vol. 7(10): 4074- 4084.
  58. Manasa Reddy, J. G., Prathyusha, K., Bindhu, H., & Ramanjaneyulu, K. (2018). EVALUATION OF IN VITRO ANTIUROLITHIATIC ACTIVITY OF MENTHA PIPERITA. Journal of Pharmaceutical Sciences amd Medicine, 22-28.
  59. Mathew, L., Sindhu, G., & Helen, A. (2014). Dolichos biflorus exhibits anti-inflammatory and antioxidant properties in an acute inflammatory model. Journal of Food and Drug Analysis, 455- 462.
  60. Mayo, C. (2020, May 05). Kidney Stones at Mayo Clinic. Retrieved f r o m M a y o C l i n i c : https://www.mayoclinic.org/diseases-conditions/kidney-stones/symp toms-causes/syc-20355755
  61. Methley, A. M., Campbell, S., Chew, C. G., McNally, R., & Sohi , S. C. (2014). PICO, PICOS and SPIDER: a comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Service Research, 579.
  62. Mikolajewicz, N., & Komarova, S. V. (2019). Meta-Analytic Methodology for Basic Research: A Practical Guide. Frontiers in Physiology.
  63. Moher, D., Liberati , A., Tetzlaff , J., & Altman , D. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med, 264-269.
  64. Morton , A., Iliescu , E., & Wilson , J. (2002). Nephrology: 1. Investigation and treatment of recurrent kidney stones. Can Med Assoc J, 166:213-8.
  65. Muhammad , F., Wiley J, & Riviere , J. (2016). Influence of some plant extracts on the transdermal absorption and penetration of marker penetrants. Cutan Ocul Toxicol, 1-7.
  66. Munn , Z. (2015). Implications for practice: should recommendations be recommended in systematic reviews? . JBI Database System Rev Implement Rep, 1-3.
  67. Niharika, M., Suchitha, N., Akhila, S., Himabindhu, J., & Dr. Ramayaneyulu, K. (2018). Evaluation of In Vitro Antiurolithiatic Activity of Gossypium Herbaceum. Jounal of Pharmaceutical Sciences and Research, 1236-1237
  68. Obidoa, O., Parker, E., Parker, E., & Nkechi, J. (2010). Phtochemical Analysis of Cocos Nucifera L. Journal of Pharmacy Research 2010, 3(2) 280-286.
  69. Pan, S. Y., Litscher, G., Gao, S. H., Zhou, S. F., Yu, Z. L., Chen, H. Q., et al. (2014). Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources. Evidence-Based Complementary and Alternative Medicine, 2014.
  70. Panee, J. (2015). Potential Medicinal Application and Toxicity Evaluation of Extracts from Bamboo Plants. Journal of Medicinal Plant Research, Vol 9(23): 681-892.
  71. Panyakaew, S., & Fotios, S. (2011). New thermal insulation boards made from coconut husk and bagasse. energy and Buildings, 43(7):1732-1739.
  72. Papatsoris , A., Skolarikos , A., & Buchholz , N. (2012). Intracorporeal laser lithotripsy. Arab J Uro, 10:301-06.
  73. Partlett, C., & Riley, R. D. (2016, October 7). Random effects metaanalysis: Coverage performance of 95% confidence and prediction intervals following REML estimation. Statistics in Medicine
  74. Petrovska, B. B. (2012). Historical Review of Medicinal Plant's Usage. Pharmacognosy Reviews, 1-5.
  75. Phatak, R. S., & Hendre, A. S. (2015). In-Vitro Antiurolithiatic Activity in Kalanchoe pinnata Extract. India: Department of Biochemistry.
  76. Prasad, P. V. (2000). Atharvaveda and its materia medica. ulletin of the Indian Institute of History of Medicine (Hyderabad).
  77. Purpurowicz, Z. (2010). Treatment procedures for urolithiasis. Pol Ann Med, 17:123-28.
  78. Qian, X., Wan, J., Xu, J., Liu, C., Zhong, M., Zhang, J., et al. (2022, March). Epidemiological Trends of Urolithiasis at the Global, Regional, and National Levels: A Population-Based Study. International Journal of Clinical Practice.
  79. Rabiei, Z., Kopaei, M. R., Heidarian, E., Saghaei, E., & Mokhtari, S. (2013). Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat. National Library of Medicine, 353-360.
  80. Ramprasad , R., Nilsha, A., Shahul Hameed, S., Shifama, J. M., & Venkateshan, N. (2019). In- Vitro antiurolithiatic activity of aqueous extract Pavonia lasiopetala. The Journal of Drug Delivery and Theraphuetics, Vol-9 No. 2.
  81. Richardson, W., Wilson , M., Nishikawa , J., & Hayward , R. (1995). The well-built clinical question: a key to evidence-based decisions. ACPJ Club, 123(3):A12–3.
  82. Ritter , M., Krombach , P., & Michel , M. (2011). Percutaneous stone removal. EurUrolSuppl, 10:433-9.
  83. Rodríguez, P. A., & Sandoval, J. R. (2014, April 22). Datasheet. Retrieved from CABI: https://www.cabi.org/isc/datasheet/11788
  84. Saljoughian, M. (2020). The Management of Urolithiasis. U.S Pharmacist, US Pharm.2020;45(9):34-36
  85. Sayer , J., Moochhala , S., & Thomas , D. (2010). he medical management of urolithiasis. Br J Med SurgUrol, 3:87-95.
  86. Sharma, D., Dey, Y., Sikarwar , I., Sejoria , R., Wanjari, M., & Jadhav, A. (2016). IN VITRO STUDY OF AQUEOUS LEAF EXTRACT OF CHENOPODIUM ALBUM FOR INHIBITION OF CALCIUM OXALATE AND BRUSHITE CRYSTALLIZATION. Egyptian Journal of Basic and Applied Sciences, 164-171.
  87. Sharma, K., Karki, S., Thakur, N., & Attri, S. (2012). Chemical composition, functional properties and processing of carrot—a review. J Food Sci Technol, 49(1): 22-32.
  88. Shukla , A., Mandavia , D., Barvaliya, M., & Baxi , S. (2014). Evaluation of anti-urolithiatic effect ofaqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi. Avicenna J Phytomed, 151-159.
  89. Sindu, P., Aparna, M., Sravani, M., Kranthi, M., & Maheswari, R. T. (2012). EVALUATION OF SELECTED MEDICINAL PLANTS FOR ANTIUROLITHIATIC ACTIVITY. International Journal of Pharmaceutical Sciences and Research, 5029-5032.
  90. Sofowora, A., Ogundodede, E., & Onayade, A. (2013). The Role and Place of Medicinal Plants in the Strategies for Disease Prevention. African Journal of Traditional, Complementary and Alternative Medicines.
  91. Spernat , D., & Kourambas , J. (2011). Urolithiasis- medical therapies. BJU Int, 108:9-13 Stuart, A., & Mikstas, C. (2021, July 29). Tribulus Terrestris. R e t r i e v e d f r o m W e b M D : https://www.webmd.com/vitamins-and-supplements/tribulus-terrestr is-uses-and-risks
  92. Suri, H. (2019, November 22). Ethical Considerations of Conducting Systematic Reviews in Educational Research. Systematic Reviews in Educational Research, 41-54.
  93. Tongco, J. V., Aguda, R. M., & Razal, R. A. (2014). Proximate analysis, phytochemical screening, and total phenolic and flavonoid. Journal of Chemical and Pharmaceutical Research, 6(1):709-713 .
  94. Uetani , K., Nakayama , T., Ikai , H., Yonemoto , N., & Moher , D. (2009). Quality of reports on randomized controlled trials conducted in Japan: evaluation of adherence to the CONSORT statement. Intern Med, 48:307–13.
  95. Vaidya , A., & Devasagayam, T. (2007). Current status of herbal drugs in India: an overview. Journal of Clinical Biochemistry and Nutrition, 1-11.
  96. Venilla, V., & Marthal, M. A. (2015). INVITRO ANALYSIS OF PHYTOCHEMICAL AND ANTIUROLITHIATIC ACTIVITY OF VARIOUS EXTRACTS OF MELIA DUBIA LEAVES.
  97. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 4(04), 1277-1289
  98. Villar, M. (2017, January 11). Legacy Senate . Retrieved from http://legacy.senate.gov.ph/lisdata/105829062!.pdf
  99. Worcester, E., & Coe, F. (2010). Calcium kidney stones. . Clinical Practice, 2363(10):954-63.
  100. Wroblewska, K. B., de Oliveira, D., Guaratini, M. G., & Moreno, P. H. (2018). Medicinal Properties of Bamboos. Pharmacognosy Medicinal Plants, DOI: 10.5772.
  101. Y.Yan. (2016). 2 - Developments in fibers for technical nonwovens. Woodhead Publishing Series in Textile, 19-96.
  102. Yolanda, S. (2018, Agust 23). Medical Home. Retrieved from News M e d i c a l W e b s c i e n c e : https://www.news-medical.net/health/What-is-Urolithiasis.aspx
  103. Zarin, M. A., Tan, J. S., Murugan, P., & Ahmad , R. (2020). Investigation of potential anti- urolithiatic activity from different types of Musa pseudo-stem extracts in inhibition of calcium oxalate crystallization. BMC Complementary Medicine and Therapies.

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