Providing more relevant and informative assessment as regards the manner by which science teachers today interact with the learning environment that is constantly being restructured by the fast evolution of the internet technology, this study aimed to investigate whether in urbanized places in Region XI the faculty’s interest to adopt and integrate Web 2.0 technologies to supplement the traditional classroom instruction is affected by their attitude, workplace influence and capability. Specifically, it also assessed whether significant influences of attitude, workplace influence and capability on faculty interest leading to the actual usage of the said technology in the classroom exist. Descriptive survey with correlation approaches was utilized in this study. The data were gathered from the 106 natural science faculty of different academic institutions of urbanized cities in Region XI, Mindanao. In addition, questionnaires were used as instruments to obtain information from the chosen respondents. Pearson product moment correlation was used to determine the strength of the linear relationship between the independent and dependent variables. Stepwise multiple regression analysis for path analysis was used to identify the indicators that best predict faculty interest. Results of the study showed that the faculty’s attitude is described by their perceptions of how useful Web 2.0 technologies are in delivering instruction. Attitude significantly influences the faculty interest to adopt Web 2.0 technologies. Perceived usefulness and compatibility were the significant predictors of attitude. Workplace influence is strongly and positively affected by peers and superiors while capability is strongly and positively affected by self-efficacy.