The emergence of multiple drug resistant Methicillin-Resistant Staphylococcus aureus (MRSA) has become a global problem. Fortunately, many plants found from Mindanaon lumads have potential curative property for different ailments. Hence, the ethnopharmacologic practice of the knobweed (Hyptis capitata) was scientifically assessed for antibacterial activity, toxicity, mutagenicity and pharmacological screenings of crude leaf extract in formulation of ointment as treatment of MRSA infections. Acute Dermal Toxicity employed female albino rabbits for 14 days. Antibacterial screenings used Kirby Bauer, Minimum Inhibitory Concentration (MIC) and potency tests. Ames test used Salmonella typhimurium TA98. Pharmacological assay was limited to physical characteristics of ointment and sensitivity (patch) test using albino rabbits (24 to 72 hours of observation). Results revealed that leaf extract was not toxic and had promising antibacterial action with 19.22 mm (±0.82) zone of inhibition on MRSA ATCC 43300 and 17.41 mm ±0.77 on clinical isolate. It had similar potency with Vancomycin at 6.54ug. MIC established the reduction of cell viability at 0.0263g/mL without revertant colonies grown; hence, it was not mutagenic. Efficacy of ointment with a hydrophilic base exhibited 16.11 mm (±1.73) zone of inhibition on MRSA ATCC and 16.12 mm (± 2.08) for clinical isolate. Neither erythema nor edema was observed.