Organizational health is an important measure of organizational effectiveness. This study aimed to assess the organizational health at Mindanao State University with indicators such as leadership, vision, employee commitment, rewards and recognition, communication, competence and skills development, teamwork and ability to adapt. Responses of 645 employees, categorized into deans and unit heads, faculty, and rank and file, were analyzed using the descriptive research design. The data were presented through frequencies, percentages and weighted means. Deans and unit heads perceived leadership and vision to be the most significant indicators of organizational health. Faculty, and rank and file likewise found these to be the most significant indicators. On the other hand, deans and unit heads perceived competence and skills development to be the least significant indicator, while faculty, and rank and file perceived rewards and recognition to contribute least to the organizational health. Overall, leadership and vision were perceived to be the most significant indicators of organizational health, while rewards and recognition least contributed to the organizational health.