Structure Elucidation of Phlegmacin Ether from Culture Broth of the Fungus, Lambertella brunneola, Y. Harada

Wilanfranco  C. Tayone,

Structure Elucidation of Phlegmacin Ether from Culture Broth of the Fungus, Lambertella brunneola, Y. Harada

Discipline: Chemistry

Abstract:

A pigment known as Phlegmacin A 8,8’-di-O-methyl ether was isolated and reported for the first time from the fungus, Lambertella brunneola, Y Harada which was cultured in a potato-sucrose medium. The compound was isolated and purified using Si02 column chromatography while the structure elucidation was based on Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS) analyses. Inital analyses suggested that Phlegmacin Ether has a 7, 10’ biaryl bridge. Apparently, it has an anti-cancer activity against HeLa and HepG2 cancer cells.