HomeThe Manila Journal of Sciencevol. 7 no. 1 (2011)

Antimicrobial Flavonoid from Hibiscus rosa-sinensis Linn

Consolacion Y. Ragasa | Leslie Ann A. Rufino

Discipline: Biochemistry



The air-dried flowers of Hibiscus rosa-sinensis Linn., commonly known as gumamela afforded 5,7,4'-trihydroxyflavanone (1), also known as naringenin, and a mixture of hydrocarbons and squalene. The structure of 1 was elucidated by extensive 1D and 2D NMR analyses. Antimicrobial tests on 1 indicated low activity against the bacterium, S. aureus and fungi, C. albicans and T. mentagrophytes. Compound 1 did not exhibit cytotoxicity against a human lung non-small cell adenocarcinoma (A549) cell line and a normal Chinese hamster ovarian (AA8) cell line.