HomeThe PCMC Journalvol. 19 no. 2 (2023)

Case report of a child with Myelin Oligodendrocyte Glycoprotein Associated Disease (MOG-AD)

Jenniel Lovely Z Poyaoan | Jean Marie B Ahorro

Discipline: medicine by specialism

 

Abstract:

Myelin oligodendrocyte glycoprotein associated disease (MOG-AD) is an inflammatory disorder of the central nervous system characterized by immune-mediated demyelination. We present a case of a patient with subacute to chronic progressive bilateral motor weakness associated with encephalopathy, which led to the diagnosis of MOG-AD. This case highlights the importance of recognizing the diverse clinical manifestations and the need for a multidisciplinary approach in the diagnosis and management of MOG-AD. In this review, we discuss the pathophysiology, diagnostic criteria, imaging findings, treatment strategies, and prognosis of MOG-AD based on the available literature.



References:

  1. Ambrosius W. et al. Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Current Insights into the Disease Pathophysiology, Diagnosis and Management. International Journal of Molecular Sciences Journal. Jan 2021 (1) 100
  2. Marignier R. et al. Myelin-oligodendrocyte glycoprotein antibody-associated disease.
  3. The Lancet Neurology. Sept 2021. Volume 20 Issue 9. P762-772
  4. Armangue T. et al. Associations of Pediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein antibodies: A Multicenter Observational Study. The Lancet Neurology. February 2021. (19)304880
  5. Wang L. Encephalitis is an important clinical component of myelin oligodendrocyte glycoprotein antibody associated demyelination: A Single- center cohort study in Shanghai China. European Jounal of Neurology. 2019, 26, 168-174
  6. Lopez-Chiriboga S et al. Association of MOG-IgG Serostatus with Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG Associated Disorders. JAMA Neurology 2018; 75: 1355
  7. Sechi E, Buciuc M, Pittock SJ, et al. Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing. JAMA Neurol 2021; 78:741