A school administrator is an educational leader who promotes the success of all students by advocating, nurturing, and sustaining a school culture and instructional program conducive to student learning and professional growth. The primary purpose in the conduct of the study was to determine whether leadership practices of school heads of Region XI can be predicted by their efficacy and professionalism. Quantitative non-experimental research designed was employed using multiple regression analysis involving three hundred nine-one (391) teacher- respondents selected at random assessing their respective school heads from the different elementary schools in Region XI. Further, results showed that professionalism and efficacy significantly predict the school heads’ leadership practices. Therefore, Professionalism significantly influences leadership practices of school heads. Efficacy significantly influences leadership practices of school heads and professionalism and efficacy are significant predictors of leadership practices of school heads. Hence, it was recommended that DepEd officials should raise the level of professionalism and efficacy of public elementary school principals in order to raise their levels of leadership practices. This can be done through trainings and effective monitoring and evaluation system to enhance the performance of the school heads in a global setting.