Home⇛The PCMC Journal⇛vol. 18 no. 1 (2022)

Diagnostic accuracy of Rapid Antigen Test in detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Infection. chronic kidney disease pediatric patients: a randomized controlled study

Jill J Jaime | Raymundo W Lo | Farrah Kristine F Santiago

Discipline: medicine by specialism

 

Abstract:

BACKGROUND: Improving the means to detect SARS-COV-2 infection is important in the ongoing battle against the COVID-19 pandemic. STANDARDTM Q COVID-19 Ag Test offers an easy to use, cheap and rapid way of testing that must be evaluated first to optimize its utility. OBJECTIVES: This study aims to evaluate the diagnostic accuracy of this test kit compared with Reverse Transcription Polymerase Chain Reaction (RT-PCR) for SARS-COV-2 diagnosis. METHODS: Using retrospective cross-sectional study, seventy seven (77) nasopharyngeal swabs in viral transport media were used to determine the sensitivity, specificity, positive predictive value and negative predictive value of STANDARDTM Q COVID-19 Ag Test compared with the reference method, RT-PCR. RESULTS: Among all participants, the rapid antigen test has a sensitivity of 9.86%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 8.57%. The sensitivity increases among symptomatic participants and when Ct value is less than 20 to 25.00% and 31.58%, respectively. CONCLUSION: Despite the low sensitivity, STANDARDTM Q COVID-19 Ag Test has a high specificity and positive predictive value and could be a cheap and efficient test in the proper clinical context. Its use in conjunction with RT-PCR for those who tested negative initially should be emphasized in the implementation of the existing policies.



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