The Effectiveness of Povidone Iodine in Treating Otomycosis as Compared with Clotrimazole: A Systematic Review and Meta-analysis

Efraim Jeric  T. Eustacio,; Arthur  T. Magboo,

The Effectiveness of Povidone Iodine in Treating Otomycosis as Compared with Clotrimazole: A Systematic Review and Meta-analysis

Efraim Jeric T Eustacio | Arthur T Magboo

Abstract:

Background Otomycosis is a fungal infection of the middle ear, external auditory canal and tympanic membrane which clinically presents as pruritus, otalgia, persistent otorrhea characterized as white greasy cottonlike debris or discharge and hearing loss. Some patients show edema of external ear, colorless ear discharge with perforated tympanic membrane, erythema of the external auditory canal epithelium and tympanic membrane. It is a common problem encountered in the out-patient clinic which is usually managed with clotrimazole otic drops. This study was conducted using different journals regarding treatment of otomycosis and the efficacy of povidone iodine as compared with clotrimazole. Objectives This meta-analysis aimed to determine the effectiveness of povidone iodine as compared to clotrimazole in treating otomycosis in adult patients (above 18 years of age). Methods A literature search was done using databases including PubMed, HERDIN, Cochrane, Science Direct, and ClinicalTrials.gov. Related literature was screened and included when it satisfied the following criteria: (1) published between 2011 and May 2022, (2) evaluated the use of povidone iodine and clotrimazole in treating otomycosis, (3) participants were adults more than 18 years of age, and (4) study design consisted of randomized controlled trials. Data was analyzed using the RevMan 5.4.1 software. Subgroup analyses were conducted according to the effectivity of povidone iodine and clotrimazole in different duration of treatment, whether there was no response, partial response or good response to treatment. Expected results For dichotomous variables, relative risk ratios with a 95% confidence interval were obtained, which would be considered significant if the confidence interval did not cross the value of 1. For continuous data, the mean difference with a 95% confidence interval were obtained, which would be considered significant if it did not cross the value of 0.

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