Cosmeceutical Potential of Artocarpus camansi Fruit Peel Extract as Bioactive Ingredient in Topical Serum Formulation
Christine Joy N. Caballero-blazo | Richie G. Bayuran
Discipline: health sciences (non-specific)
Abstract:
The global use of plant-based cosmetics
has increased dramatically as consumers
become more aware of the long-term health
advantages of natural products. The Philippines,
a tropical Asian country, has numerous local
plant resources with promising medicinal value
while preserving its unique biodiversity and
inherited medicinal value. The present study
deals with the utilization of Artocarpus camansi
fruit peel extract as bioactive component with
pharmacological activity in cosmetic formulation. This experimental research
involved extraction of phenolic compounds, formulation of topical serum, and
in vitro investigation of antibacterial, anti-inflammatory, and photoprotective
activity of A. camansi topical serum (ACTS). The pure extract yielded 22.5 mg/g total phenolic content. Among the three formulations, 5% ACTS was found
to be the most effective antibacterial, anti-inflammatory, and photoprotective
topical serum compared to 1% and 3%. The results of one-way ANOVA revealed
that there was a statistically significant difference among the formulations
compared to the positive and negative controls. Post-hoc confirmed that the
positive controls provided the highest activity among the treatments. A. camansi
fruit peel extract can therefore be identified as a potential bioactive ingredient in
cosmetic formulations for serums which can be effective in improving skin and
providing protection from the external environment.
References:
- Abbas, N., Arshad, M. S., Hussain, A., Irfan, M., Ahsan, M., Rasool, M. F., & ur Rehman, M. H. (2017). Development and validation of a spectroscopic method for the simultaneous analysis of miconazole nitrate and hydrocortisone acetate in pharmaceutical dosage form. Tropical Journal of Pharmaceutical Research, 16(2), 413-420.
- Afaq, F., & K Katiyar, S. (2011). Polyphenols: skin photoprotection and inhibition of photocarcinogenesis. Mini reviews in medicinal chemistry, 11(14), 1200-1215.
- Ante, I., Aboaba, S., Siddiqui, H., & Choudhary, M. I. (2016). Essential oils of the leaf, stem-bark, and nut of Artocarpus camansi: Gas Chromatography-Mass Spectrometry analysis and activities against multidrug-resistant bacteria. Journal of Herbs, Spices & Medicinal Plants, 22(3), 203-210.
- Battie, C., Jitsukawa, S., Bernerd, F., Del Bino, S., Marionnet, C., & Verschoore, M. (2014). New insights in photoaging, UVA induced damage and skin types. Experimental dermatology, 23, 7-12.
- Bernerd, F., Passeron, T., Castiel, I., & Marionnet, C. (2022). The damaging effects of long UVA (UVA1) rays: a major challenge to preserve skin health and integrity. International journal of molecular sciences, 23(15), 8243.
- Buddhisuharto, A. K., Pramastya, H., Insanu, M., & Fidrianny, I. (2021). An updated review of phytochemical compounds and pharmacology activities of Artocarpus genus. Biointerface Res Appl Chem, 11(6), 14898-14905.
- Claustra, A. L., Madulid, R. S., Aguinaldo, A. M., Espeso, E. I., Guevara, B. Q., Nonato, M. G., ... & Ysrael, M. C. (2005). A guidebook to plant screening: phytochemical and biological. University of santo tomas publishing house, espana, manila, 105-120.
- Del Giudice, P. (2020). Skin infections caused by Staphylococcus aureus. Acta dermato-venereologica, 100(9).
- Dunaway, S., Odin, R., Zhou, L., Ji, L., Zhang, Y., & Kadekaro, A. L. (2018). Natural antioxidants: multiple mechanisms to protect skin from solar radiation. Frontiers in pharmacology, 9, 392.
- Edslev, S. M., Olesen, C. M., Nørreslet, L. B., Ingham, A. C., Iversen, S., Lilje, B., ... & Andersen, P. S. (2021). Staphylococcal communities on skin are associated with atopic dermatitis and disease severity. Microorganisms, 9(2), 432.
- Elizalde-Jiménez, I. G., Ruiz-Hernández, F. G., Carmona-Cruz, S. A., Pastrana-Arellano, E., Aquino-Andrade, A., Romo-González, C., ... & García-Romero, M. T. (2024). Global Antimicrobial Susceptibility Patterns of Staphylococcus aureus in Atopic Dermatitis: A Systematic Review and Meta-Analysis. JAMA dermatology.
- Hashim, N., Rahmani, M., Sukari, M. A., Ali, A. M., Alitheen, N. B., Go, R., & Ismail, H. B. (2010). Two new xanthones from Artocarpus obtusus. Journal of Asian Natural Products Research, 12(2), 106-112.
- Hashim, P., Sidek, H., Helan, M. H. M., Sabery, A., Palanisamy, U. D., & Ilham, M. (2011). Triterpene composition and bioactivities of Centella asiatica. Molecules, 16(2), 1310-1322.
- Hu, S., Zhang, X., Chen, F., & Wang, M. (2017). Dietary polyphenols as photoprotective agents against UV radiation. Journal of Functional Foods, 30, 108-118.
- Jayasinghe, U. L. B., Samarakoon, T. B., Kumarihamy, B. M. M., Hara, N., & Fujimoto, Y. (2008). Four new prenylated flavonoids and xanthones from the root bark of Artocarpus nobilis. Fitoterapia, 79(1), 37-41.
- Kaur, C. D., & Saraf, S. (2010). In vitro sun protection factor determination of herbal oils used in cosmetics. Pharmacognosy research, 2(1), 22.
- Kaur, C. D., & Saraf, S. (2011). Photochemoprotective activity of alcoholic extract of Camellia sinensis. International journal of pharmacology, 7(3), 400-404.
- Li, A. N., Li, S., Zhang, Y. J., Xu, X. R., Chen, Y. M., & Li, H. B. (2014). Resources and biological activities of natural polyphenols. Nutrients, 6(12), 6020-6047.
- Loza-Mejía, M. A., & Salazar, J. R. (2015). Sterols and triterpenoids as potential anti-inflammatories: Molecular docking studies for binding to some enzymes involved in inflammatory pathways. Journal of Molecular Graphics and Modelling, 62, 18-25.
- Makmur, L., Syamsurizal, Tukiran, Achmad, S. A., Aimi, N., Hakim, E. H., ... & Takayama, H. (2000). Artoindonesianin C, a new xanthone derivative from Artocarpus teysmanii. Journal of natural products, 63(2), 243-244.
- Mansur, J. D. S., Breder, M. N., Mansur, M. C., & Azulay, R. D. (1986). Determination of sun protection factor by spectrophotometry. An Bras Dermatol, 61(3), 121-124.
- Martínez, A., Estévez, J. C., & Silva-Pando, F. J. (2012). Antioxidant activity, total phenolic content and skin care properties of 35 selected plants from Galicia (NW Spain). Frontiers in Life Science, 6(3-4), 77-86.
- Mbanga, L., Mulenga, M., Mpiana, P. T., Bokolo, K., Mumbwa, M., & Mvingu, K. (2014). Determination of sun protection factor (SPF) of some body creams and lotions marketed in Kinshasa by ultraviolet spectrophotometry. Int. J. Adv. Res. Chem. Sci, 1(8), 7-13.
- Mishra, A. K., Mishra, A., & Chattopadhyay, P. (2012). Assessment of in vitro sun protection factor of Calendula officinalis L.(asteraceae) essential oil formulation. Journal of Young Pharmacists, 4(1), 17-21.
- Mohamad, N. R., Abd Gani, S. S., Wahab, R. A., & Zaidan, U. H. (2018). In-Vitro Photoprotective Activities of Different Solvent Extraction of Hibiscus Sabdariffa. Malaysian Journal of Analytical Sciences, 22(6), 1078-1083.
- Nasution, R. O. S. N. A. N. I., Fitrah, C. N., Helwati, H. I. R. A., Murniana, A. B., & Cutchamzurni, C. (2018). Antidiabetes activities extract hexane from the peels of Artocarpus camansi Blanco fruit. Asian J. Pharm. Clin. Res, 11(13), 12-17.
- Nasution, R., Muhabbah, N., Helwati, H., Bahi, M., Marianne, M., & Amna, U. (2020). Isolation of lupeol acetate from fruit peels of Artocarpus camansi. Journal of Advanced Pharmaceutical Technology & Research, 11(3), 148-156.
- Odabasoglu, F., Aslan, A., Cakir, A., Suleyman, H., Karagoz, Y., Halici, M., & Bayir, Y. (2004). Comparison of antioxidant activity and phenolic content of three lichen species. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 18(11), 938-941.
- Piotrowski, W., & Kubica, R. (2021). Integration of the process for production of ethyl acetate by an enhanced extraction process. Processes, 9(8), 1425.
- Ragone, D. (2006). Artocarpus camansi (breadnut). The Breadfruit Institute, National Tropical Botanical Garden. Hawaii.
- Salaheen, S., Nguyen, C., Hewes, D., & Biswas, D. (2014). Cheap extraction of antibacterial compounds of berry pomace and their mode of action against the pathogen Campylobacter jejuni. Food Control, 46, 174-181.
- Salonga, R. B., Hisaka, S., & Nose, M. (2014). Effect of the hot water extract of Artocarpus camansi leaves on 2, 4, 6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity in mice. Biological and Pharmaceutical Bulletin, 37(3), 493-497.
- Sayre, R. M., Agin, P. P., LeVee, G. J., & Marlowe, E. (1979). A comparison of in vivo and in vitro testing of sunscreening formulas. Photochemistry and Photobiology, 29(3), 559-566.
- Sidahmed, H. M., Hashim, N. M., Amir, J., Abdulla, M. A., Hadi, A. H. A., Abdelwahab, S. I., ... & Mohan, S. (2013). Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine, 20(10), 834-843.
- Silalahi, M. (2022). Keluwih (Artocarpus camansi Blanco): Potential utilization as foodstuff and its bioactivity. GSC Biological and Pharmaceutical Sciences, 19(2), 310-315.
- Tsai, P. W., De Castro-Cruz, K. A., Shen, C. C., Chiou, C. T., & Ragasa, C. Y. (2013). Chemical constituents of Artocarpus camansi. Pharmacognosy Journal, 5(2), 80-82.
- Vianney, Y. M., Amanda, N., Pieknell, K., Johan, C. W., & Hardjo, P. H. (2018). Evaluation of the antioxidant and antibacterial activity of breadnut (Artocarpus camansi Blanco) leaf extracts. Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural Product Radiance (NPR)], 9(2), 151-159.
- Wood, C., & Murphy, E. (2000). Sunscreen efficacy: a burning issue. Global cosmetic industry, 167(2), 38-44.
- Wulf, H. C. (2009). Sunscreens. Non-Surgical Treatment of Keratinocyte Skin Cancer, 167-176.
- Yahfoufi N., Alsadi N., Jambi M., Matar C., (2018). The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients, 10(11):1618. https://doi.org/10.3390/nu10111618
- Zahara, I., Anwar, E., Laksmitawati, D. R., & Rahmat, D. (2023). Antioxidant activity cultivated of soursop (Annona muricata L.) leaves extract in Jayasari village, Pangandaran District, west java. Journal of Natural Product for Degenerative Diseases, 1(1), 1–7. https://doi.org/10.58511/jnpdd.v1i1.5317
Full Text:
Note: Kindly Login or Register to gain access to this article.
ISSN 2244-0445 (Online)
ISSN 2012-3981 (Print)