HomePhilippine Journal of Veterinary Medicinevol. 43 no. 2 (2006)

Effect of Prolonged Daily Administration of Aspirin on the Histochemistry of the Kidney of Goats (Capra hircus) Estrus-Synchronized with Prostaglandin F2a

Grace D. De Ocampo | Irene Consuela L. Cruz | Bella C. Cruzana | Yv Agung Riono

Discipline: Veterinary Medicine




This study was conducted to determine the effect of 60 days of daily administration of aspirin or acetylsalicylic acid (ASA) on the amount of fat, glycogen, calcium, and hemoglobin in the goat kidney. Twelve apparently healthy, sexually mature, estrus-synchronized female goats were equally divided into three groups. The four animals in each group were assigned randomly to four treatments. Each treatment, with three replicates, was given 0g, 10g, 20g and 30g aspirin. Tissue samples from the right or left kidney were processed routinely and stained for fat, glycogen, calcium and hemoglobin. Histochemical tests showed that fat, calcium and hemoglobin were present in moderate to large amounts in the cortex, juxtamedullary region and medulla of kidney in untreated and 10g aspirin-treated goats but substantially decreased in goats given 20g and 30 g aspirin. In contrast, glycogen was moderate in the cortex, juxtamedullary region and medulla in the former two groups but occurred in large amount in the latter two groups. The findings indicated that aspirin given daily for 60 days, at doses higher than the prescribed 10g dose, substantially decreased fat, calcium, and hemoglobin; and increased glycogen in the goat kidney.