Multidisciplinary research wields a strategic value in higher education particularly in building a new knowledge economy. The paper expounds the application of multidisciplinary research approaches in business research and the higher education strategy in improving multidisciplinary research with industries. the study used the descriptive analytic research design employing the use of web generated literature for the analysis. The results showed that the trend n business research development has been increasingly competitive and more complex. However, the problems surrounding such a phenomenon can be good opportunities for universities to take part for their contribution to industries. Multidisciplinary research is seen as an appropriate means to solve such complex problems because this type of research is more comprehensive in providing solutions. The resources need to be prepared, concerning financial capital, management systems, research resources, facilities and infrastructure. the study concludes that by improving the quality and productivity of multidisciplinary research with the industries, performance of universities will improve in terms of quality education, and teaching process, research productivity, recognition by society leading to the university's sustainability.