Home⇛The PCMC Journal⇛vol. 8 no. 2 (2010)

Intravenous immunoglobulin treatment failure in patients with Kawasaki disease in a tertiary hospital Quezon City, Philippines

Cynthia Espino | Minnie Chavez | Jonas Del Rosario

Discipline: medicine by specialism

 

Abstract:

OBJECTIVES: The objectives of this study were to describe the profile of patients with Kawasaki Disease treated with intravenous immunoglobulin (IVIG) , determine rate of treatment failure and to identify factors that may affect treatment failure. DESIGN: Descriptive, retrospective, case control SETTING: Tertiary Hospital PATIENTS AND METHODS: A total 280 patients were included in the study, Group 1 included children considered to be treatment responders and the Group 2 were considered to be treatment non responders. SPSS version 15 was used and both descriptive measures and multivariate analysis were done. Descriptive measures include mean, standard deviation, odds ratio, contingency tables and cross tabulation. RESULTS: The clinical characteristics of the patients from the two groups were compared and only the average number of hospital days were found to be significant with p < 0.001. The difference between the laboratory examinations of the two groups including WBC, hematocrit, platelet count, CRP and ESR were found to be not statistically significant except for neutrophil count with p value < 0.05. CONCLUSIONS AND RECOMMENDATIONS: Future studies with a larger population group and follow up of patients diagnosed with Kawasaki Disease is recommended.



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