HomePhilippine Journal of Veterinary Medicinevol. 45 no. 2 (2008)

Effect of Long-Term Daily Intake of Aspirin on the Morphology of the Kidney of Goat (Capra hircus) Estrus-Synchronized with Prostaglandin F2a

Grace D. De Ocampo | Dr. Irene Consuelo R. Lcruz | Bella C. Cruzana | Yv Agung Riono

Discipline: Veterinary Medicine

 

Abstract:

This study was conducted to determine the effect of prolonged daily administration of aspirin on the microscopic structure of the goat kidney. Twelve apparently healthy, sexually mature, estrus-synchronized female goats were assigned randomly into four treatments and given aspirin (T1=O g, T2 =10 g, T3 =20 g, T4 =30 g) once a day for 60 days. Tissues from cranial, middle and caudal portions of right or left kidney were processed routinely, stained with hematoxylin and eosin, alcian blue pH 2.5 and Jones method for kidney (JMK) (Luna, 1968) and observed under the light microscope. The capsule thickness, diameter of renal corpuscle and glomerulus, and distance between the most superficial corpuscles and the renal capsule were measured (u); and the mean values +/-standard error of means of numerical data were computed. Results indicated that the kidneys of 0 g and 10 g ASA-treated goats presented a typical architecture. Those of the 20 g and 30 g ASA-t reated goats showed morphological alterations such as a wavy renal capsule, consolidated renal tissue, contracted renal corpuscle, fused glomerular lobules and obliterated glomerular space and tubules, which suggest shrinkage of renal tissue. Another alteration, the hypercellular cortical and medullary tissues may indicate a hypersensitive or inflammatory reaction. The findings suggest that aspirin given for 60 days at double or triple the prescribed 10g dose, substantially altered the structure of renal tissue but was not toxic enough to produce severe pathological lesions in the goat kidney.